Toxicology study assessing efficacy and safety of repeated administration of lipid/DNA complexes to mouse lung
Abstract
For gene therapy to improve lung function in cystic fibrosis (CF) subjects, repeated administration of the gene transfer agent over the lifetime of patients is likely to be necessary. This requirement limits the utility of adenoviral and adeno-associated viral vectors (both previously evaluated in CF gene therapy trials) because of induced adaptive immune responses that render repeated dosing ineffective. For CF gene therapy trials, non-viral...
Paper Details
Title
Toxicology study assessing efficacy and safety of repeated administration of lipid/DNA complexes to mouse lung
Published Date
Nov 7, 2013
Journal
Volume
21
Issue
1
Pages
89 - 95
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