Aloperine executes antitumor effects against multiple myeloma through dual apoptotic mechanisms

Aloperine, a natural alkaloid constituent isolated from the herb Sophora alopecuroides displays anti-inflammatory properties in vitro and in vivo. Our group previously demonstrated that aloperine significantly induced apoptosis in colon cancer SW480 and HCT116 cells. However, its specific target(s) remain to be discovered in multiple myeloma (MM) and have not been investigated. Human myeloma cell lines (n = 8), primary myeloma cells (n = 12),...