Methods for Meta-Analyses of Genome-wide Association Studies: Critical Assessment of Empirical Evidence

There has been a steep increase in the number of meta-analyses of genome-wide association (GWA) studies aimed at identifying genetic variants with increasingly smaller effects, but pressure to publish findings of new genetic associations has limited the time available for careful consideration of all of their methodological aspects. The authors surveyed the literature (2007–2010) to provide empirical evidence on the methods used in GWA...