Compact designer TALENs for efficient genome engineering
Abstract
Transcription activator-like effector nucleases are readily targetable ‘molecular scissors’ for genome engineering applications. These artificial nucleases offer high specificity coupled with simplicity in design that results from the ability to serially chain transcription activator-like effector repeat arrays to target individual DNA bases. However, these benefits come at the cost of an appreciably large multimeric protein complex, in which...
Paper Details
Title
Compact designer TALENs for efficient genome engineering
Published Date
Apr 23, 2013
Journal
Volume
4
Issue
1
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