Tumor Metastasis: Molecular Insights and Evolving Paradigms
Abstract
Metastases represent the end products of a multistep cell-biological process termed the invasion-metastasis cascade, which involves dissemination of cancer cells to anatomically distant organ sites and their subsequent adaptation to foreign tissue microenvironments. Each of these events is driven by the acquisition of genetic and/or epigenetic alterations within tumor cells and the co-option of nonneoplastic stromal cells, which together endow...
Paper Details
Title
Tumor Metastasis: Molecular Insights and Evolving Paradigms
Published Date
Oct 14, 2011
Journal
Volume
147
Issue
2
Pages
275 - 292
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