Antagonistic effects of TGF-β1 and MSF on fibroblast migration and hyaluronic acid synthesis: Possible implications for dermal wound healing

The migration of adult skin fibroblasts into threedimensional collagen gel matrices is differentially affected by cell density, with subconfluent cells displaying a significantly elevated level of migration compared to confluent ones. Fetal fibroblasts differ from adult cells in that they display an elevated level of migration at both subconfluent and confluent cell densities. We have previously reported that this difference in behaviour results...