Therapeutic Effects of an Anti-Myc Drug on Mouse Pancreatic Cancer
Volume: 106, Issue: 12
Published: Oct 11, 2014
Abstract
Pancreatic ductal adenocarcinoma (PDA) is frequently driven by oncogenic KRAS(KRAS*) mutations. We developed a mouse model of KRAS*-induced PDA and, based on genetic results demonstrating that KRAS* tumorigenicity depends on Myc activity, we evaluated the therapeutic potential of an orally administered anti-Myc drug.We tested the efficacy of Mycro3, a small-molecule inhibitor of Myc-Max dimerization, in the treatment of mouse PDA (n = 9) and...
Paper Details
Title
Therapeutic Effects of an Anti-Myc Drug on Mouse Pancreatic Cancer
Published Date
Oct 11, 2014
Volume
106
Issue
12
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