Quantification of the Effect of Conformational Restriction on Supramolecular Effective Molarities

The association constants for a family of 96 closely related zinc porphyrin–pyridine ligand complexes have been measured in two different solvents, toluene and 1,1,2,2-tetrachloroethane (TCE). The zinc porphyrin receptors are equipped with phenol side arms, which can form intramolecular H-bonds with ester or amide side arms on the pyridine ligands. These association constants were used to construct 64 chemical double mutant cycles, which measure...