Evidence of carrier-mediated transport in the penetration of donepezil into the rat brain.

Volume: 99, Issue: 3, Pages: 1548 - 1566
Published: Mar 1, 2010
Abstract
The objective of this study was to characterize the mechanism that controls the transport of donepezil into the brain. The apparent brain uptake clearance (CL(app,br)) was decreased as a function of the dose of donepezil, suggesting an involvement of a saturable transport process via transporter(s) in the penetration across the blood-brain barrier (BBB). Consistent with in vivo results, the uptake of substrates for organic cation transporters...
Paper Details
Title
Evidence of carrier-mediated transport in the penetration of donepezil into the rat brain.
Published Date
Mar 1, 2010
Volume
99
Issue
3
Pages
1548 - 1566
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