The prophylactic efficacy of various simulators against intoxication with the organophosphate soman: structure-activity studies
Abstract
The effects were investigated of structural variations of the soman simulator pinacolyl dimethylphosphinate on its efficacy to prevent secondary failure of oxime-induced recovery of neuromuscular transmission and death after soman intoxication. The simulators were administered prophylactically to atropinized, HI-6 treated rats, dosed with 6 or 8 X LD50 soman. In these new simulators the pinacolyl moiety was varied, the phosphonyl oxygen atom was...
Paper Details
Title
The prophylactic efficacy of various simulators against intoxication with the organophosphate soman: structure-activity studies
Published Date
Jan 1, 1986
Volume
38
Issue
1
Pages
19 - 23
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