Beyond ALK-RET, ROS1 and other oncogene fusions in lung cancer
Abstract
Fusions of the RET and ROS1 protein tyrosine kinase oncogenes with several partner genes were recently identified as new targetable genetic aberrations in cases of non-small cell lung cancer (NSCLC) lacking activating EGFR, KRAS, ALK, BRAF, or HER2 oncogene aberrations. RET and ROS1 fusion-positive tumors are mainly observed in young, female, and/or never smoking patients. Studies based on in vitro and in vivo (i.e., mouse) models and studies of...
Paper Details
Title
Beyond ALK-RET, ROS1 and other oncogene fusions in lung cancer
Published Date
Jan 22, 2015
Volume
4
Issue
2
Pages
156 - 164
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