Dengue virus type 1 clade replacement in recurring homotypic outbreaks

Recurring dengue outbreaks occur in cyclical pattern in most endemic countries. The recurrences of dengue virus (DENV) infection predispose the population to increased risk of contracting the severe forms of dengue. Understanding the DENV evolutionary mechanism underlying the recurring dengue outbreaks has important implications for epidemic prediction and disease control.We used a set of viral envelope (E) gene to reconstruct the phylogeny of...