Design, synthesis, and biological evaluation of antibody-drug conjugates comprised of potent camptothecin analogues.

Volume: 20, Issue: 6, Pages: 1242 - 1250
Published: May 26, 2009
Abstract
Antibody-drug conjugates (ADCs) were prepared with potent camptothecin analogues attached to monoclonal antibodies (mAbs) via dipeptide or glucuronide-based linkers. Aniline-containing camptothecin analogues were employed to provide a site of linker attachment via carbamate bonds that would be stable in circulation. The camptothecin analogues, 7-butyl-10-amino-camptothecin and 7-butyl-9-amino-10,11-methylenedioxy-camptothecin, are generally...
Paper Details
Title
Design, synthesis, and biological evaluation of antibody-drug conjugates comprised of potent camptothecin analogues.
Published Date
May 26, 2009
Volume
20
Issue
6
Pages
1242 - 1250
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