The evolution of Fox genes and their role in development and disease

Fox genes encode a large and ancient family of transcriptional regulators with a wide range of biological functions. This article describes the evolution of this family, its importance in development and disease, and the basis of its functional diversification. The forkhead box (Fox) family of transcription factors, which originated in unicellular eukaryotes, has expanded over time through multiple duplication events, and sometimes through gene...