Biochemical Parameters After Cholecalciferol Repletion in Hemodialysis: Results From the VitaDial Randomized Trial

Background The 2009 KDIGO (Kidney Disease: Improving Global Outcomes) chronic kidney disease–mineral and bone disorder clinical practice guideline suggests correcting 25-hydroxyvitamin D3 (25[OH]D) levels < 30 ng/mL in patients treated with maintenance hemodialysis, but does not provide a specific treatment protocol. Study Design 2-center, double-blind, randomized, 13-week, controlled trial followed by a 26-week open-label study. Setting &...