B-cell subpopulations in humans and their differential susceptibility to depletionwith anti-CD20 monoclonal antibodies
Abstract
In humans, different B-cell subpopulations can be distinguished in peripheral bloodand other tissues on the basis of differential expression of various surface markers.These different subsets correspond to different stages of maturation, activation anddifferentiation. B-cell depletion therapy based on rituximab, an anti-CD20 mAb, iswidely used in the treatment of various malignant and autoimmune diseases. Rituximabinduces a very significant...
Paper Details
Title
B-cell subpopulations in humans and their differential susceptibility to depletionwith anti-CD20 monoclonal antibodies
Published Date
Mar 25, 2013
Journal
Volume
15
Issue
1
Pages
1 - 8
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