Reciprocal regulation of hepatic and adipose lipogenesis by liver X receptors in obesity and insulin resistance.
Abstract
Liver X receptors (LXRs) regulate lipogenesis and inflammation, but their contribution to the metabolic syndrome is unclear. We show that LXRs modulate key aspects of the metabolic syndrome in mice. LXRαβ-deficient-ob/ob (LOKO) mice remain obese but show reduced hepatic steatosis and improved insulin sensitivity compared to ob/ob mice. Impaired hepatic lipogenesis in LOKO mice is accompanied by reciprocal increases in adipose lipid storage,...
Paper Details
Title
Reciprocal regulation of hepatic and adipose lipogenesis by liver X receptors in obesity and insulin resistance.
Published Date
Jul 2, 2013
Journal
Volume
18
Issue
1
Pages
106 - 117
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Notes
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