Heritability of complex white matter diffusion traits assessed in a population isolate

Introduction Diffusion weighted imaging (DWI) methods can noninvasively ascertain cerebral microstructure by examining pattern and directions of water diffusion in the brain. We calculated heritability for DWI parameters in cerebral white (WM) and gray matter (GM) to study the genetic contribution to the diffusion signals across tissue boundaries. Methods Using Old Order Amish (OOA) population isolate with large family pedigrees and high...