Application of in vivo microdialysis for studying the efficacy of protective preparations against sulfur mustard penetrating the skin

Subcutaneous microdialysis was employed for monitoring thiodiglycol (2,2′‐thiodiethanol, TDG) levels with the aim of characterizing the transdermal penetration of topically applied liquid sulfur mustard (2,2′‐dichlorodiethyl sulfide, SM) in rats. TDG levels, evaluated in 20 min dialysates collected over a 6 h sampling period, were plotted against time after pooling. Linear correlation was identified between the SM dose and the mean areas under...