Prognostic role of lactate dehydrogenase in solid tumors: A systematic review and meta-analysis of 76 studies

In cancer cells, metabolism is shifted to aerobic glycolysis with lactate production coupled with a higher uptake of glucose as the main energy source. Lactate dehydrogenase (LDH) catalyzes the reduction of pyruvate to form lactate, and serum level is often raised in aggressive cancer and hematological malignancies. We have assessed the prognostic value of LDH in solid tumors.A systematic review of electronic databases was conducted to identify...