BRCA1 interacts directly with the Fanconi anemia protein FANCA
Abstract
Fanconi anemia (FA) is a rare autosomal recessive disease characterized by skeletal defects, anemia, chromosomal instability and increased risk of leukemia. At the cellular level FA is characterized by increased sensitivity to agents forming interstrand crosslinks (ICL) in DNA. Six FA genes have been cloned and interactions among individual FANC proteins have been found. The FANCD2 protein co-localizes in nuclear foci with the BRCA1 protein...
Paper Details
Title
BRCA1 interacts directly with the Fanconi anemia protein FANCA
Published Date
Oct 2, 2002
Journal
Volume
11
Issue
21
Pages
2591 - 2597
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Notes
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