Immunochemical Detection of Sulfur Mustard Adducts with Keratins in the Stratum Corneum of Human Skin
Abstract
As part of a program to develop methods for diagnosis of exposure to chemical warfare agents, we developed immunochemical methods for detection of adducts of sulfur mustard to keratin in human skin. Three partial sequences of keratins containing glutamine or asparagine adducted with a 2-hydroxyethylthioethyl group at the omega-amide function were synthesized and used as antigens for raising antibodies. After immunization, monoclonal antibodies...
Paper Details
Title
Immunochemical Detection of Sulfur Mustard Adducts with Keratins in the Stratum Corneum of Human Skin
Published Date
Dec 4, 2001
Volume
15
Issue
1
Pages
21 - 25
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