Activated Notch signaling is required for hepatitis B virus X protein to promote proliferation and survival of human hepatic cells
Abstract
Hepatitis B virus X protein (HBx) is a multifunctional oncoprotein which plays a crucial role in the pathogenesis of hepatocellular carcinoma (HCC). However, the exact mechanisms remain controversial. Here we show that HBx strongly stimulated cell growth, promoted cell cycle progression and inhibited apoptosis of human non-tumor hepatic cell line L02 cells. It also accelerated tumor formation of L02 cells in BALB/c nude mice. Furthermore, Notch...
Paper Details
Title
Activated Notch signaling is required for hepatitis B virus X protein to promote proliferation and survival of human hepatic cells
Published Date
Dec 1, 2010
Journal
Volume
298
Issue
1
Pages
64 - 73
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