Where is hippocampal activity in the cascade of Alzheimer’s disease biomarkers?

This scientific commentary refers to ‘Amyloid-β deposition in mild cognitive impairment is associated with increased hippocampal activity, atrophy and clinical progression’, by Huijbers et al. (doi:10.1093/brain/awv007). Recent neuroimaging advances have helped transform the diagnosis of Alzheimer’s disease. Previously, imaging and other biomarkers were used only to rule out other causes of dementia. However, with the new National Institute on...