Salidroside decrease expression of hypoxia-inducible factor-1α in cultured human lung cancer cells

Salidroside is a active constituent of traditional herbal medicine Rhodiola rosea, responsible for the neuroprotective, antidepressant, anxiolytic and anti-tumor actions. However, the mechanism of its anticancer effect is unclear as there have little molecular studies regardingcell migration, invasion, cell cycle, induction of apoptosis in healthy and cancerous cells. Hypoxia-inducible factor-1α (HIF-α) plays an important role in tumor growth,...