Inheritance Pattern and Clinical Aspects of 93 Iranian Patients with Chronic Granulomatous Disease

Background Chronic granulomatous disease (CGD) is a rare immunodeficiency due to a genetic defect in one of the NADPH-oxidase components. We studied CGD inheritance forms (autosomal recessive (AR) or X-linked (XL)) and AR-CGD subtypes in Iran. Methods Clinical and functional investigations were conducted in 93 Iranian CGD patients from 75 families. Results Most of the patients were AR-CGD (87.1%). This was related to consanguineous marriages (p=...