Effects of aflibercept on primary RPE cells: toxicity, wound healing, uptake and phagocytosis

Volume: 98, Issue: 10, Pages: 1448 - 1452
Published: Jul 17, 2014
Abstract

Background/aim

Anti-VEGF treatment is the therapy of choice in age-related macular degeneration, and is also applied in diabetic macular oedema or retinal vein occlusion. Recently, the fusion protein, aflibercept, has been approved for therapeutic use. In this study, we investigate the effects of aflibercept on primary RPE cells.

Methods

Primary RPE cells were prepared from freshly slaughtered pigs’ eyes. The impact of...
Paper Details
Title
Effects of aflibercept on primary RPE cells: toxicity, wound healing, uptake and phagocytosis
Published Date
Jul 17, 2014
Volume
98
Issue
10
Pages
1448 - 1452
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