Randomized Trial of Postoperative Reirradiation Combined With Chemotherapy After Salvage Surgery Compared With Salvage Surgery Alone in Head and Neck Carcinoma

Purpose Full-dose reirradiation combined with chemotherapy has been shown to be feasible after salvage surgery with acceptable toxicity. The Groupe d’Etude des Tumeurs de la Tête et du Cou and Groupe d’Oncologie Radiothérapie Tête Et Cou groups performed a randomized study to assess its efficacy. Patients and Methods Between 1999 and 2005, 130 patients with head and neck cancer were treated with salvage surgery and randomly assigned to full-dose...