Time-dependent changes in lipid metabolism in mice with methionine choline deficiency-induced fatty liver disease
Abstract
Methionine and choline-deficient diet (MCD)-induced fatty liver is one of the best-studied animal models of fatty liver disease. The present study was performed to clarify the relative contributions of individual lipid metabolic pathways to the pathogenesis of MCD-induced fatty liver. Hepatic lipogenesis mediated by the sterol regulatory element-binding protein (SREBP-1c) was increased at 1 week, but not at 6 weeks, of MCD feeding. On the other...
Paper Details
Title
Time-dependent changes in lipid metabolism in mice with methionine choline deficiency-induced fatty liver disease
Published Date
Dec 1, 2011
Journal
Volume
32
Issue
6
Pages
571 - 578
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History