Influence of chitosan on cell viability and proliferation in three dimensional collagen gels

The development of suitable three-dimensional matrices for the maintenance of cellular viability and differentiation is critical for applications in tissue engineering and cell biology. The structure and composition of the extracellular matrix (ECM) has been shown to modulate cell behavior with respect to shape, movement, proliferation and differentiation. Although collagen and chitosan have separately been proposed as in vitro ECM materials,...