BMPR2 loss in fibroblasts promotes mammary carcinoma metastasis via increased inflammation
Abstract
Bone Morphogenetic Protein (BMP) receptors mediate a diverse range of signals to regulate both development and disease. BMP activity has been linked to both tumor promoting and suppressive functions in both tumor cells and their surrounding microenvironment. We sought to investigate the requirement for BMPR2 in stromal fibroblasts during mammary tumor formation and metastasis. We utilized FSP1 (Fibroblast Specific Protein-1) promoter driven Cre...
Paper Details
Title
BMPR2 loss in fibroblasts promotes mammary carcinoma metastasis via increased inflammation
Published Date
Jan 1, 2015
Journal
Volume
9
Issue
1
Pages
179 - 191
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Notes
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