Complement Activation in Acetaminophen-Induced Liver Injury in Mice

Volume: 341, Issue: 2, Pages: 377 - 385
Published: Feb 7, 2012
Abstract
Overdose with acetaminophen (APAP) results in acute liver failure in humans and experimental animals. Complement comprises more than 30 proteins that can participate in tissue injury and/or repair, but the role of complement activation in APAP-induced hepatotoxicity has not been evaluated. Treatment of male, C57BL6J mice with APAP (200-400 mg/kg) resulted in liver injury as evidenced by increased activity of alanine aminotransferase (ALT) in...
Paper Details
Title
Complement Activation in Acetaminophen-Induced Liver Injury in Mice
Published Date
Feb 7, 2012
Volume
341
Issue
2
Pages
377 - 385
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