Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance
Abstract
The role of epithelial-to-mesenchymal transition (EMT) in metastasis is a longstanding source of debate, largely owing to an inability to monitor transient and reversible EMT phenotypes in vivo. Here we establish an EMT lineage-tracing system to monitor this process in mice, using a mesenchymal-specific Cre-mediated fluorescent marker switch system in spontaneous breast-to-lung metastasis models. We show that within a predominantly epithelial...
Paper Details
Title
Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance
Published Date
Nov 26, 2015
Journal
Volume
527
Issue
7579
Pages
472 - 476
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