Quantification of Ricinine in Rat and Human Urine: A Biomarker for Ricin Exposure
Abstract
Ricin is a toxalbumin derived from the castor bean plant, Ricinus communis. Ricinine is an alkaloid (3-cyano-4-methoxy-N-methyl-2-pyridone) that shares a common plant source with ricin, and its presence in urine infers ricin exposure. A new quantification method for ricinine was developed that uses solid-phase extraction to prepare 1-mL urine samples (81% recovery) for a 5-min, isocratic high-performance liquid chromatography method, followed by...
Paper Details
Title
Quantification of Ricinine in Rat and Human Urine: A Biomarker for Ricin Exposure
Published Date
Apr 1, 2005
Volume
29
Issue
3
Pages
149 - 155
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