Oral immunization with recombinant enterovirus 71 VP1 formulated with chitosan protects mice against lethal challenge

Enterovirus 71 (EV71) is the etiologic agent of hand-foot-and-mouth disease (HFMD) in the Asia-Pacific region, Many strategies have been applied to develop EV71 vaccines but no vaccines are currently available. Mucosal immunization of the VP1, a major immunogenic capsid protein of EV71, may be an alternative way to prevent EV71 infection. In this study, mucosal immunogenicity and protect function of recombinant VP1 protein (rVP1) in formulation...