Diabetes Induces Aberrant DNA Methylation in the Proximal Tubules of the Kidney

Volume: 26, Issue: 10, Pages: 2388 - 2397
Published: Feb 4, 2015
Abstract
Epigenetic mechanisms may underlie the progression of diabetic kidney disease. Because the kidney is a heterogeneous organ with different cell types, we investigated DNA methylation status of the kidney in a cell type-specific manner. We first identified genes specifically demethylated in the normal proximal tubules obtained from control db/m mice, and next delineated the candidate disease-modifying genes bearing aberrant DNA methylation induced...
Paper Details
Title
Diabetes Induces Aberrant DNA Methylation in the Proximal Tubules of the Kidney
Published Date
Feb 4, 2015
Volume
26
Issue
10
Pages
2388 - 2397
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