The role of RELN in lissencephaly and neuropsychiatric disease

Volume: 144, Issue: 1, Pages: 58 - 63
Published: Jan 5, 2007
Abstract
Reelin is an extracellular matrix-associated protein important in the regulation of neuronal migration during cerebral cortical development. Point mutations in the RELN gene have been shown to cause an autosomal recessive human brain malformation termed lissencephaly with cerebellar hypoplasia (LCH). Recent work has raised the possibility that reelin may also play a pathogenic role in other neuropsychiatric disorders. We sought, therefore, to...
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Paper Details
Title
The role of RELN in lissencephaly and neuropsychiatric disease
Published Date
Jan 5, 2007
Volume
144
Issue
1
Pages
58 - 63
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