Dantrolene – A review of its pharmacology, therapeutic use and new developments
Abstract
Human malignant hyperthermia is a life-threatening genetic sensitivity of skeletal muscles to volatile anaesthetics and depolarizing neuromuscular blocking drugs occurring during or after anaesthesia. The skeletal muscle relaxant dantrolene is the only currently available drug for specific and effective therapy of this syndrome in man. After its introduction, the mortality of malignant hyperthermia decreased from 80% in the 1960s to < 10% today....
Paper Details
Title
Dantrolene – A review of its pharmacology, therapeutic use and new developments
Published Date
Mar 16, 2004
Journal
Volume
59
Issue
4
Pages
364 - 373
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History