Shift in GATA3 functions, and GATA3 mutations, control progression and clinical presentation in breast cancer

Volume: 16, Issue: 6
Published: Nov 20, 2014
Abstract
GATA binding protein 3 (GATA3) is a regulator of mammary luminal cell differentiation, and an estrogen receptor (ER) associated marker in breast cancer. Tumor suppressor functions of GATA3 have been demonstrated primarily in basal-like breast cancers. Here, we focused on its function in luminal breast cancer, where GATA3 is frequently mutated, and its levels are significantly elevated. GATA3 target genes were identified in normal- and luminal...
Paper Details
Title
Shift in GATA3 functions, and GATA3 mutations, control progression and clinical presentation in breast cancer
Published Date
Nov 20, 2014
Volume
16
Issue
6
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