T Cell Factor 1 Regulates Thymocyte Survival via a RORγt-Dependent Pathway
Abstract
Survival of CD4(+)CD8(+) double-positive (DP) thymocytes plays a critical role in shaping the peripheral T cell repertoire. However, the mechanisms responsible for the regulation of DP thymocyte lifespan remain poorly understood. In this work, we demonstrate that T cell factor (TCF)-1 regulates DP thymocyte survival by upregulating RORγt. Microarray analysis revealed that RORγt was significantly downregulated in TCF-1(-/-) thymocytes that...
Paper Details
Title
T Cell Factor 1 Regulates Thymocyte Survival via a RORγt-Dependent Pathway
Published Date
Dec 1, 2011
Journal
Volume
187
Issue
11
Pages
5964 - 5973
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