Macrophage Wnt-Calcineurin-Flt1 signaling regulates mouse wound angiogenesis and repair.

Blood20.30
Volume: 121, Issue: 13, Pages: 2574 - 2578
Published: Mar 28, 2013
Abstract
The treatment of festering wounds is one of the most important aspects of medical care. Macrophages are important components of wound repair, both in fending off infection and in coordinating tissue repair. Here we show that macrophages use a Wnt-Calcineurin-Flt1 signaling pathway to suppress wound vasculature and delay repair. Conditional mutants deficient in both Wntless/GPR177, the secretory transporter of Wnt ligands, and CNB1, the essential...
Paper Details
Title
Macrophage Wnt-Calcineurin-Flt1 signaling regulates mouse wound angiogenesis and repair.
Published Date
Mar 28, 2013
Journal
Volume
121
Issue
13
Pages
2574 - 2578
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