Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases
Volume: 112, Issue: 42
Published: Sep 14, 2015
Abstract
TREX1 is an exonuclease that digests DNA in the cytoplasm. Loss-of-function mutations of TREX1 are linked to Aicardi-Goutieres Syndrome (AGS) and systemic lupus erythematosus (SLE) in humans. Trex1(-/-) mice exhibit autoimmune and inflammatory phenotypes that are associated with elevated expression of interferon (IFN)-induced genes (ISGs). Cyclic GMP-AMP (cGAMP) synthase (cGAS) is a cytosolic DNA sensor that activates the IFN pathway. Upon...
Paper Details
Title
Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases
Published Date
Sep 14, 2015
Volume
112
Issue
42
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