The pro-inflammatory environment in recalcitrant diabetic foot wounds

Lower extremity ulceration is one of the serious and long‐term diabetic complications rendering a significant social burden in terms of amputation and quality‐of‐life reduction. Diabetic patients experience a substantial wound‐healing deficit. These lesions are featured by an exaggerated and prolonged inflammatory reaction with a significant impairment in local bacterial invasion control. Experimental and clinical evidences document the...