Soy Isoflavones and Bone Health: The Relationship Is Still Unclear

Evidence of the effect of purified soy isoflavones and soy protein isolates containing isoflavones on bone health in rats and in humans is inconsistent. Differences may be because of synergies or antagonisms among the isoflavones, threshold or biphasic dose effects, life stage of animals or human subjects, estrogen status, and environment–genetic interactions, including the ability to produce metabolites upon ingestion of isoflavones. At this...