Evaluation of methylation modification in E-cadherin gene and its application in the improvement of breast cancer

CDH1 (E-cadherin), which mediates cell-cell interaction and polarity, is known as glycoprotein in cytoskeleton. The objective of this study was to evaluate CDH1 expression loss as the metastatic marker by defining the methylation pattern in the promoter region and determining whether or not the methylation pattern changes in correlation with a kind of tumor, grade and metastatic status. Fifty patients with breast carcinoma were enrolled in this...