Examination of Phenotypic Changes in Peripheral Blood‐Derived Dendritic Cells Following Exposure to a Contact Allergen: Cell Surface Marker and Gene Expression

The evaluation of the potential to induce allergic contact dermatitis is an important component of the overall safety assessment process of a new chemical entity that may be encountered through the skin. Currently, the murine local lymph node assay (LLNA) is the method of choice for assessing skin sensitization potential. However, despite the success of the LLNA as an alternative test method that results in a reduction in and refinement of...