Two new diterpenes from the seeds of Caesalpinia minax Hance.

Published on Aug 14, 2015in Journal of Asian Natural Products Research1.345
· DOI :10.1080/10286020.2015.1039998
Lian Lian1
Estimated H-index: 1
,
Xiao-Bin Li1
Estimated H-index: 1
(SPU: Shenyang Pharmaceutical University)
+ 3 AuthorsHuiyuan Gao12
Estimated H-index: 12
Sources
Abstract
Molecules with diterpene skeletons often possess valuable medicinal properties. Two new diterpenes 1α,6α,7β-triacetoxy-5α-hydroxy-14β-ethyl-O-vouacapane (1) and 2α-acetoxy-14,15-cyclopimara-7β,16-diol (2) were isolated from the seeds of Caesalpinia minax Hance. Their structures were established on the basis of extensive spectroscopic analyses, including HR-ESI-MS, UV, IR, 1D, and 2D NMR (HSQC, HMBC, NOESY) methods. The stereochemical structure of 1 was confirmed via the circular dichroism spectrum and calculated ECD experiment. The inhibitory activity of nitric oxide production of RAW264.7 macrophages stimulated by lipopolysaccharide of compounds 1 and 2 was evaluated, and compound 1 was found to show significant inhibitory effect.
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