Extracellular Matrix Secretion by Cardiac Fibroblasts

MicroRNAs (miRNAs), in particular miR-29b and miR-30c, have been implicated as important regulators of cardiac fibrosis.To perform a proteomics comparison of miRNA effects on extracellular matrix secretion by cardiac fibroblasts.Mouse cardiac fibroblasts were transfected with pre-/anti-miR of miR-29b and miR-30c, and their conditioned medium was analyzed by mass spectrometry. miR-29b targeted a cadre of proteins involved in fibrosis, including...