Restriction of intestinal stem cell expansion and the regenerative response by YAP

Nature64.80
Volume: 493, Issue: 7430, Pages: 106 - 110
Published: Jan 3, 2013
Abstract
A remarkable feature of regenerative processes is their ability to halt proliferation once an organ's structure has been restored. The Wnt signalling pathway is the major driving force for homeostatic self-renewal and regeneration in the mammalian intestine. However, the mechanisms that counterbalance Wnt-driven proliferation are poorly understood. Here we demonstrate in mice and humans that yes-associated protein 1 (YAP; also known as YAP1)--a...
Paper Details
Title
Restriction of intestinal stem cell expansion and the regenerative response by YAP
Published Date
Jan 3, 2013
Journal
Volume
493
Issue
7430
Pages
106 - 110
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