Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity
Abstract
Toxicity resulting from excessive intra-synaptic serotonin, historically referred to as serotonin syndrome, is now understood to be an intra-synaptic serotonin concentration-related phenomenon. Recent research more clearly delineates serotonin toxicity as a discreet toxidrome characterized by clonus, hyper-reflexia, hyperthermia and agitation. Serotonergic side-effects occur with serotonergic drugs, and overdoses of serotonin re-uptake...
Paper Details
Title
Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity
Published Date
Oct 1, 2005
Volume
95
Issue
4
Pages
434 - 441
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